Our article breaks down the top 10 list of diseases without cures. That’s right! We may not have to worry about dying prematurely anymore!
Perhaps you have, at one time or another, wondered about your family’s medical history. You can see a lot about what you’re most vulnerable to! Of course, I’m talking about diseases. If you or a loved one has suffered from cancer, blood disorders, blindness, cystic fibrosis, and even death, we may have a solution.
Top 10 List Of Diseases Without Cures
Cancer has taken so many lives in history that by the time we finally abolish it forever, it will still be later than we all hoped. However, thanks to CRISPR, it could be one of the first successful clinical trials.
One is running in China as we speak, tryingto treat patients with oesophagus cancer. They are extracting immune T cells from trial patients and modifying them to remove the gene holding a PD-1 Protein, to which some tumours bind to keep them from attacking.
So, the cells are placed back in the patient, much more capable of attacking cancer. Similar studies are being done in other countries including the United States with leukaemia, lymphoma, and other cancers. Soon, the whole world could very well be cancer-free.
9. Blood Disorders
This at number 9 in the list of diseases without cures. Using CRISPR, the U.S. and Europe started testing patients to attempt to treat beta-thalassemia and sickle cell disease. What, you’ve never heard of them?
Well, about 100,000 in the United States could fill you in as to how it feels. The disorders affect the transport of oxygen in the blood.
The treatment consists of harvesting bone marrow stem cells to CRISPR them -yeah, I’ musing that as a verb now – to make them produce haemoglobin, a protein that carries oxygen and binds to it better.
Haemophilia is another blood disorder that CRISPR technology could tackle and possibly eradicate.
Okay, so CRISPR changed the game and it’s going to keep coming up, let’s just face that fact now. As we see it tackle some of the worlds scariest diseases, it’s also going to go after genetic blindness.
There’s a specific type of mutation that causes a variety of hereditary forms of blindness and CRISPR can attack that exact mutation and modify it. So what are they going after?
Leber Congenital Amaurosis, the most common cause of inherited childhood blindness which remains without treatment.CRISPR is bringing light into children eyes. What else could you ask for?
Finally!What we’ve been waiting for since the 70sand 80s AIDS crisis when people were dying left and right and marginalized people suffered in silence.CRISPR to the rescue, once again!
For one, it could cut the DNA of HIV, which could be used to attack the virus in its inactive form. This tricky method is exactly what keeps doctors from treating it now.
They might also try to make humans resistant to the HIV infection, which would be even cooler! Right now, some people already have a natural resistance to HIV, thanks to a mutation of a protein that doesn’t allow the virus to bind to it.
This was used in a trial last year done inChina.They edited human embryos to make them resistant to HIV, causing outrage in the medical community.
See, some studies seemed to suggest that these babies could be at a higher risk of dying younger. It seems that they’ll be doing more testing before continuing to test on others.
6. Cystic Fibrosis
Now here’s another genetic disease that we’re about to kick to the curb. This one is known for causing severe respiratory problems.
Right now, there are several ways to treat the illness, but mainly they’re for treating symptoms. People with Cystic Fibrosis only live for around 40 years.
With today’s technology… yes, CRISPR, we could edit the mutations that cause this, located in a gene called CFTR. Since using CRISPR in human lung cells is a viable method proven by scientists, they can start testing on humans very soon.
It’s not a clear path, though, because cystic Fibrosis can be caused by a variety of mutations, so several methods will have to be created, tested, and applied. For now, they’ll look at the most common and some of the rarest that currently have no treatment.
5. Muscular Dystrophy
This disease, also called Duchenne muscular dystrophy, is caused by mutations in the DMD gene. This disease causes those who suffer from it to have progressive muscular degeneration, for which there’s no treatment, just care.CRISPR research in mice shows that it could be used to fix some of the mutations behind the disease.
Recently, researchers in the US unveiled a method that used CRISPR to cut at 12 of what they call mutation hotspots, which covered the majority of the estimated 3,000 mutations that cause this disease.
It’s also probable that in the future they’ll work on an approach that would remove the whole section of the mutated protein, making it shorter, but still functional.
4. Huntington’s Disease
This condition, a neurodegenerative disease with a strong genetic component, is caused by abnormal DNA repetition within the gene. The more copies an individual has, the earlier the disease manifests.
It can be devastating for many people, young or old. Scientists are now looking at ways of making the editing tool safe because the off-target effects of CRISPR could have tragic consequences.
They included something that seems straight out of a Dexter’s Laboratory episode. The version of CRISPR that they’ve modified for this purpose has a “self-destruct button”, while another version has opted for pairing the CRISPR version with an enzyme that makes it more precise.
Millions of people around the world suffer from Alzheimer’s, and that number is only increasing. The search to cure the memory black hole that is Alzheimer’s may not be completely hopeless, however.
What they’re doing first is defining measurable markers for the disease much in the same way that cholesterol is a marker for heart disease.
This would lead to early detection and faster treatment. It could also lead to prevention. New treatments include gene therapy, helping reduce the buildups of plaque in the brain that leads to dementia.
Soon, we can have less fear of losing our loved ones to this awful disease long before they pass away.
2. Childhood Seizures
Some of the most intriguing illnesses in today’s world, written about by world-renowned doctors and New York Times writers like Dr Lisa Sanders, have some sort of seizure involved.
Epilepsy is one of the causes of childhood seizing and there is one subset of childhood epilepsy that could cure very soon.
This subset focused on seizures caused by genetic and environmental factors, that with treatment can allow the children to overcome it.
This is because of how we’ve come to understand genetically determined epilepsy and technology that allows advanced imaging of the brain to identify abnormalities.
So, you think death is not an illness? That’s the first symptom. Just kidding, but thinking of death as an illness is the first step scientists have taken to start solving the problem.
They’re starting to consider options like genetic editing, detaching our consciousness, and even just using stem cell research and bionic organs.
Biologic death is the illness we’re tryingto eradicate here. Death and disease are the first things to tackle.150,000 people die every single day!
So, if ageing is declared a disease, can we take it away all together? Some doctors say we’re just a decade or two from at least expanding our lifetimes dramatically.
We’ll see what happens with that, but if you’re interested, Google more about Transhumanism! Thanks for reading this article of a list of diseases without cures.
So which list of diseases without cures or human malady do you want to see remedied most? Let us know in the comments. Before the moment “passes away” be sure to share it with your friends as a sure cure for boredom!
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